Lipid profile: calculated measures
Calculates Friedewald and Sampson LDL, non-HDL, remnant cholesterol and lipid ratios.
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Calculation
Result
- LDL cholesterol (LDL-C)
- 3.49 mmol/L
- LDL by Friedewald
- 3.42 mmol/L
- LDL by Sampson
- 3.49 mmol/L
- Non-HDL cholesterol
- 4.10 mmol/L
- Remnant cholesterol
- 0.61 mmol/L
- Atherogenic index of plasma (AIP)
- 0.06 index
- Atherogenic coefficient (Klimov)
- 3.15 index
- Castelli indices I / II
- 4.15 / 2.68 ratio
- TG/HDL ratio
- 1.15 ratio
Sampson (2020) estimate at TG ≤ 800 mg/dL; not a direct LDL measurement.
Friedewald (1972) estimate at TG < 400 mg/dL; accuracy depends on clinical context.
Sampson (2020) estimate at TG ≤ 800 mg/dL; not a direct LDL measurement.
Total cholesterol minus HDL; a clinician determines individual targets.
Total cholesterol minus HDL and estimated LDL. Arithmetic estimate without a universal risk category.
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories.
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories.
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories.
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories.
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories. Indices use measured LDL if entered, otherwise the Sampson estimate within its applicable range. Reference ranges are population benchmarks from the cited sources. Laboratories use their own ranges, and interpretation depends on clinical context: discuss the result with your physician.
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How it is calculated
Friedewald: LDL = total cholesterol − HDL − TG/5, all in mg/dL, when TG <400 mg/dL. Sampson (2020) is used when TG ≤800 mg/dL; negative estimates are not shown. AIP = log10(TG/HDL), both in mmol/L.
Formula
Friedewald: LDL = total cholesterol − HDL − TG/5, all in mg/dL, when TG <400 mg/dL. Sampson (2020) is used when TG ≤800 mg/dL; negative estimates are not shown. AIP = log10(TG/HDL), both in mmol/L.
Limits of the method
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories.
Sources of the method
- Friedewald WT et al. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem, 1972
- Sampson M et al. A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia. JAMA Cardiol, 2020
- Dobiásová M et al. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem, 2001
- Mach F et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J, 2020
This calculation is for reference only and is not medical advice, a diagnosis or a prescription. If you have a medical condition, are pregnant, take medication or have any doubts, discuss the result with a physician or a qualified nutrition professional.
How to use the calculation
Enter the starting values
Use actual values and the appropriate units.
Adjust the parameters
Adjust the starting assumptions for your situation.
Read the result
Consider the model limitations; a calculation is not a measurement.
Frequently asked questions
What does the calculation show?
Calculates Friedewald and Sampson LDL, non-HDL, remnant cholesterol and lipid ratios. Friedewald: LDL = total cholesterol − HDL − TG/5, all in mg/dL, when TG <400 mg/dL. Sampson (2020) is used when TG ≤800 mg/dL; negative estimates are not shown. AIP = log10(TG/HDL), both in mmol/L.
What limitations apply?
LDL targets depend on overall cardiovascular risk. These measures do not establish individual risk, a diagnosis or a need for medicines. Ratios and AIP are shown without universal normality categories. Indices use measured LDL if entered, otherwise the Sampson estimate within its applicable range.
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What next
Formula breakdowns, biomarker reference ranges and nutrition articles with cited sources are in the NutriFit knowledge base.
Go to the knowledge base