Anion Gap and Delta Ratio Calculator

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃).

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Calculation

Initial values of 12 and 24 mmol/L are calculation assumptions. Enter reference values for your laboratory method.

Hypoalbuminemia lowers the anion gap; the correction adds 0.25 mmol/L for every g/L below 40.

Result

Albumin-corrected anion gap
12.0 mmol/L

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃).

Uncorrected anion gap
12.0 mmol/L

Na − (Cl + HCO₃); equals the corrected gap at normal albumin

Delta ratio (ΔAG / ΔHCO₃)
Not calculated: the corrected gap must exceed the selected reference and bicarbonate must be below its reference.

Not calculated: the corrected gap must exceed the selected reference and bicarbonate must be below its reference.

Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context. Reference ranges are population benchmarks from the cited sources. Laboratories use their own ranges, and interpretation depends on clinical context: discuss the result with your physician.

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How it is calculated

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃).

Formula

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃). Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context.

Limits of the method

Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context.

Sources of the method

This calculation is for reference only and is not medical advice, a diagnosis or a prescription. If you have a medical condition, are pregnant, take medication or have any doubts, discuss the result with a physician or a qualified nutrition professional.

How to use the calculation

1

Enter the starting values

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃).

2

Adjust the parameters

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃). Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context.

3

Read the result

Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context.

Frequently asked questions

What does the calculation show?

Anion gap = Na − Cl − HCO₃; albumin adjustment = 0.25 × (40 − albumin in g/L). Delta ratio = (corrected gap − selected reference) / (reference bicarbonate − HCO₃).

What limitations apply?

Reference values depend on the laboratory method. Delta is calculated only with a positive numerator and denominator. A number alone cannot establish a diagnosis without pH, blood gases and clinical context.

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What next

Formula breakdowns, biomarker reference ranges and nutrition articles with cited sources are in the NutriFit knowledge base.

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